Cut the tip off the applicator. Apply 2 drops of gel to each side of your dog's mouth once daily. After application, your dog will naturally begin licking its lips, helping the gel spread across the teeth and gums. For best results, withhold food and water for 30 minutes before and after application. To help remove plaque and tartar more quickly, you can also brush your dog's teeth using a TropiClean Fresh Breath toothbrush and the gel.